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M94A3102.TXT
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1994-10-25
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Document 3102
DOCN M94A3102
TI Gender differences in infectious HIV viral burden among injecting drug
users. ALIVE Study.
DT 9412
AU Farzadegan H; Vlahov D; Nelson K; Johns Hopkins University, Baltimore,
MD 21205.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):153 (abstract no. PB0040). Unique
Identifier : AIDSLINE ICA10/94369473
AB OBJECTIVE: To compare infectious viral load among men and women IDUs.
METHOD: A total of 285 IDUs, of whom 89 (31%) were women at various CD4
levels were studied. (Median CD4 = 394 range 2-2375). Infectious viral
load was determined by cocultivation of serial 5-fold dilution of one
million PBMC, with normal PBMC (IUPM). CD4 lymphocyte phenotyping was
performed using 2 color flow cytometric measurements. RESULTS: The
median IUPM was 8. The proportion of men and women with IUPM greater or
less than 8 IUPM (medium) was similar in IDUs with CD4 count greater
than 400. Among IDUs with CD4 less than 400, 73% (74/101) of men and 58%
(25/43) women had IUPM > or = 8 (P = 0.07). Multiple logistic regression
analysis found CD4 level less than 400 was significantly associated with
IUPM > or = 8 (P = 0.0001). However gender was not independently
significant (P = 0.1). CONCLUSION: Viral load was significantly higher
in IDUs with low CD4 level but similar between male and female IDUs
after controlling for CD4 level.
DE Antigens, CD/BLOOD Antigens, CD4/BLOOD Cells, Cultured Comparative
Study Female Human HIV/*ISOLATION & PURIF HIV
Infections/*IMMUNOLOGY/MICROBIOLOGY
Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY Male *Sex Characteristics Sex
Factors Substance Abuse, Intravenous/IMMUNOLOGY/*MICROBIOLOGY T4
Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).